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Posted Thu, Mar, 13,2014
Published today in Gene Regulation and Systems Biology is a new concise review article by Andrey N. Luchnik. Read more about this paper below:
Title
DNA Conformational Transitions Induced by Supercoiling Control Transcription in Chromatin
Abstract
Regulation of transcription in eukaryotes is considered in the light of recent findings demonstrating the presence of negative and positive superhelical tension in chromatin. This tension induces conformational transitions in DNA duplex. Particularly, the transition into A-form renders DNA accessible and waylaying for initiation of transcription producing RNA molecules long known to belong to the A-conformation. Competition between conformational transitions in various DNA sequences for the energy of elastic spring opens a possibility for understanding of fine tuning of transcription at a distance.
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