Posted Tue, Mar, 11,2014
Published today in Analytical Chemistry Insights is a new rapid communication article by Fouad Chiadmi and Joël Schlatter. Read more about this paper below:
Title
Buprenorphine and Norbuprenorphine Determination in Mice Plasma and Brain by Gas Chromatography–Mass Spectrometry
Abstract
A gas chromatography tandem mass spectrometry method for quantification of buprenorphine (BUP) and norbuprenorphine (NBUP) in brain and plasma samples from mice was developed and validated. Analytes were extracted from the brain or plasma by solid phase extraction and quantified within 20 minutes. Calibration was achieved by linear regression with a 1/x weighting factor and d4-buprenorphine internal standard. All products were linear from 1 to 2000 ng/mL with a correlation of determination >0.99. Assay accuracy and precision of back-calculated standards were within ±10%. The lower limit of quantification for both BUP and NBUP from the brain and plasma was 1 ng/mL. This sensitive and specific method can be used for the investigation of BUP mechanism of action and clinical profile.
Click here to learn more about the article, download it and comment
Posted in: Articles Published
News Categories
Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesAs an author, I had a wonderful experience working with the editorial team of Nutrition and Metabolic Insights. Starting from the review process to proof processing and finalization of publication, I enjoyed the helpful nature and prompt response of the editorial and managerial team, and found them highly professional. The online review process was very well organized. I would love to work with the publication house in the future too. Keep up the spirit. ...
Facebook Google+ Twitter
Pinterest Tumblr YouTube