Posted Thu, Dec, 19,2013
Published today in Clinical Medicine Insights: Case Reports is a new case report article by Lindsey Prochaska, Christopher Dakhil and Sharad Mathur. Read more about this paper below:
Title
Blastic Plasmacytoid Dendritic Cell Neoplasm
Abstract
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive myeloid neoplasm derived from plasmacytoid monocytes. The most common presentation involves cutaneous manifestations, which are often accompanied by bone marrow involvement. The tumor cells reveal an immature blastic appearance and diagnosis is based on the expression of cluster of differentiation (CD)4 and CD56. The literature reports a high relapse rate and poor prognosis when treated with leukemia-type induction chemotherapy alone; however, long-term remission is attainable with allogeneic stem cell transplantation in the first complete remission. Here, we report the dismal course of a patient with BPDCN with cutaneous and bone marrow involvement unable to undergo an aggressive intervention.
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