Posted Thu, Nov, 28,2013
Published today in Cancer Growth and Metastasis is a new review article by Sathana Dushyanthen, Davina A.F. Cossigny and Gerald M.Y. Quan. Read more about this paper below:
Title
The Osteoblastic and Osteoclastic Interactions in Spinal Metastases Secondary to Prostate Cancer
Abstract
Prostate cancer (PC) is one of the most common cancers arising in men and has a high propensity for bone metastasis, particularly to the spine. At this stage, it often causes severe morbidity due to pathological fracture and/or metastatic epidural spinal cord compression which, if untreated, inevitably leads to intractable pain, neurological deficit, and paralysis. Unfortunately, the underlying molecular mechanisms driving growth of secondary PC in the bony vertebral column remain largely unknown. Further investigation is warranted in order to identify therapeutic targets in the future. This review summarizes the current understanding of PC bone metastasis in the spine, highlighting interactions between key tumor and bone-derived factors which influence tumor progression, especially the functional roles of osteoblasts and osteoclasts in the bone microenvironment through their interactions with metastatic PC cells and the critical pathway RANK/RANKL/OPG in bone destruction.Click here to learn more about the article, download it and comment
Posted in: Articles Published
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Interview with Professor Jamie DaviesMy experience of publishing my article with Libertas Academia was excellent. They professionally handled the review process. The quality of the reviews were high. I look forward to publishing my scientific papers again with Libertas Academia.
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