Posted Tue, Nov, 26,2013
Published today in Clinical Medicine Insights: Women's Health is a new original research article by Hiroki Hamada, Kei Shimoda and Masaharu Seno. Read more about this paper below:
Title
Chemo-enzymatic Synthesis of Propionyl-ester-linked Taxol-monosaccharide Conjugate and its Drug Delivery System Using Hybrid-Bio-nanocapsules Targeting Brain Glioma Cells
Abstract
Taxol is recognized as one of the most potent anticancer agents used in the treatment of breast and ovarian cancers, which are common cancers in women. To overcome its shortcomings, that is, its low water-solubility that reduces drug loading capacity of DDS carriers when incorporating taxol, chemo-enzymatic synthesis of ester-linked taxol-glucose conjugate, i.e., 7-propionyltaxol 2"-O-α-D-glucoside, as a water soluble taxol prodrug was achieved by using a-glucosidase as a glucosylation catalyst. The water-solubility of 7-propionyltaxol 2"-O-α-D-glucoside (25 mM) was 63 fold higher than that of taxol (0.4 mM). The pre-S1 peptide which displays on the surface of bio-nanocapsules, which are nanoparticles composed of the hepatitis B virus surface antigen, was replaced with the antibody affinity motif of protein A. Conjugation of such bio-nanocapsules with anti-human epidermal growth factor receptor antibody gave hybrid bio-nanocapsules. The hybrid bio-nanocapsules were effective for delivering 7-propionyltaxol 2"-O--D-glucoside to human brain glioma cells. 7-Propionyltaxol 2"-O-α-D-glucoside was effectively hydrolyzed to give taxol in 95% by human glioma cells. The drug loading capacity of hybrid bio-nanocapsules incorporating 7-propionyltaxol 2"-O-α-D-glucoside was 120 times higher than that incorporating taxol itself.
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Interview with Professor Jamie DaviesWorking with the Editor at the Journal of Medical Education and Curricular Development, and the publishing staff at Libertas Academica was an excellent experience. From submission to revision, the editorial process was smooth and fair. I had such a good experience that I will consider journals of Libertas Academica at the top of my list the next time I want to submit a manuscript.
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