Posted Wed, Sep, 04,2013
Published today in Biomarker Insights is a new perspective article by Antoine Kossaify, Annie Garcia, Sami Succar, Antoine Ibrahim, Nicolas Moussallem, Mikhael Kossaify and Gilles Grollier, STAR-P Consortium. Read more about this paper below:
Title
Perspectives on the Value of Biomarkers in Acute Cardiac Care and Implications for Strategic Management
Abstract
Biomarkers in acute cardiac care are gaining increasing interest given their clinical benefits. This study is a review of the major conditions in acute cardiac care, with a focus on biomarkers for diagnostic and prognostic assessment. Through a PubMed search, 110 relevant articles were selected. The most commonly used cardiac biomarkers (cardiac troponin, natriuretic peptides, and C-reactive protein) are presented first, followed by a description of variable acute cardiac conditions with their relevant biomarkers. In addition to the conventional use of natriuretic peptides, cardiac troponin, and C-reactive protein, other biomarkers are outlined in variable critical conditions that may be related to acute cardiac illness. These include ST2 and chromogranin A in acute dyspnea and acute heart failure, matrix metalloproteinase in acute chest pain, heart-type fatty acid binding protein in acute coronary syndrome, CD40 ligand and interleukin-6 in acute myocardial infarction, blood ammonia and lactate in cardiac arrest, as well as tumor necrosis factor-alpha in atrial fibrillation. Endothelial dysfunction, oxidative stress and inflammation are involved in the physiopathology of most cardiac diseases, whether acute or chronic. In summary, natriuretic peptides, cardiac troponin, C-reactive protein are currently the most relevant biomarkers in acute cardiac care. Point-of-care testing and multi-markers use are essential for prompt diagnostic approach and tailored strategic management.
Click here to learn more about the article, download it and comment
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Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesClinical Medicine Insights: Case Reports was very thorough. I appreciated the way you painstakingly followed all the processes of verifying submitted manuscripts for publication. It shows that you do not just allow anything to pass for publication! Please keep the good work. Science and indeed biological research should be verifiable and dynamic.
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