Posted Fri, Aug, 30,2013
Published today in Cancer Informatics is a new original research article by Chindo Hicks, Lucio Miele, Tejaswi Koganti and Srinivasan Vijayakumar. Read more about this paper below:
Title
Comprehensive Assessment and Network Analysis of the Emerging Genetic Susceptibility Landscape of Prostate Cancer
Abstract
Background: Recent advances in high-throughput genotyping have made possible identification of genetic variants associated with increased risk of developing prostate cancer using genome-wide associations studies (GWAS). However, the broader context in which the identified genetic variants operate is poorly understood. Here we present a comprehensive assessment, network, and pathway analysis of the emerging genetic susceptibility landscape of prostate cancer.
Methods: We created a comprehensive catalog of genetic variants and associated genes by mining published reports and accompanying websites hosting supplementary data on GWAS. We then performed network and pathway analysis using single nucleotide polymorphism (SNP)-containing genes to identify gene regulatory networks and pathways enriched for genetic variants.
Results: We identified multiple gene networks and pathways enriched for genetic variants including IGF-1, androgen biosynthesis and androgen signaling pathways, and the molecular mechanisms of cancer. The results provide putative functional bridges between GWAS findings and gene regulatory networks and biological pathways.
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Interview with Professor Jamie DaviesI had a great experience publishing our paper in Breast Cancer: Basic and Clinical Research. The editorial team is very friendly and helpful. I was updated frequently during the entire review and publishing process. The review process is very reasonable and fair. The editor in charge has good judgement on review comments. I would recommend this journal to any researchers who conduct breast cancer research.
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