Posted Fri, Aug, 23,2013
Published today in Clinical Medicine Insights: Oncology is a new review article by Joelle El-Amm, Nihar Patel, Ashley Freeman and Jeanny B. Aragon-Ching. Read more about this paper below:
Title
Metastatic Castration-Resistant Prostate Cancer: Critical Review of Enzalutamide
Abstract
Enzalutamide, previously known as MDV300, is an oral, second-generation androgen receptor (AR) signaling inhibitor or antagonist that was approved by the Food and Drug Administration in 2012 for the treatment of metastatic castrate-resistant prostate cancer (mCRPC) postdocetaxel. Preclinical studies have demonstrated impressive affinity to the AR compared to the first-generation AR inhibitors. The landmark Phase III AFFIRM trial demonstrated improved overall survival benefit compared to placebo in addition to improvement in all tested parameters. Enzalutamide is currently being studied in several trials prechemotherapy and in earlier settings of prostate cancer. This review will discuss the mechanism of action of enzalutamide, its pharmacokinetics, the preclinical and clinical trials that led to its approval, the ongoing clinical trials, its safety and efficacy, as well as patterns of resistance, and discusses its place in therapy within the context of several recently approved agents for mCRPC.
Click here to learn more about the article, download it and comment
Posted in: Articles Published
News Categories
Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesThe experience of publishing with Clinical Medicine Insights: Ear, Nose and Throat was amazing. The prompt review and author friendly system made the process very simple and fast. The best part was the meticulous guidance provided by the editor in every step of the publication. I am very happy to be associated with such a dedicated and thoroughly professional team. I would certainly recommend others to submit their works to this journal and experience the ...
Facebook Google+ Twitter
Pinterest Tumblr YouTube