Posted Tue, Aug, 20,2013
Published today in Drug Target Insights is a new short review by Md. Lutful Amin. Read more about this paper below:
Title
P-glycoprotein Inhibition for Optimal Drug Delivery
Abstract
P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents are substrates to it and it impedes the absorption, permeability, and retention of the drugs, extruding them out of the cells. It is overexpressed in cancer cells and accountable for obstructing cell internalization of chemotherapeutic agents and for developing transporter mediated resistance by cancer cells during anti-tumor treatments. As it jeopardizes the success of drug delivery and cancer targeting, strategies are being developed to overcome P-gp mediated drug transport. This concise review represents a brief discussion on P-gp mediated drug transport and how it hinders the success of various therapies. Its main focus is on various strategies used to tackle this curb in the field of drug delivery and targeting.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesIt was a pleasure to work with your editorial board. Responses were extremely rapid and very useful. You must be the most e-literate journal with which I have interacted with, and that is many, including the big guys. I am proud to have our review published in Magnetic Resonance Insights.
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