Posted Fri, Jun, 21,2013
Published today in Bioinformatics and Biology Insights is a new original research article by Jurjen W. Westra, Walter K. Schlage, Arnd Hengstermann, Stephan Gebel, Carole Mathis, Ty Thomson, Ben Wong, Vy Hoang, Emilija Veljkovic, Michael Peck, Rosemarie B. Lichtner, Dirk Weisensee, Marja Talikka, Renee Deehan, Julia Hoeng and Manuel C. Peitsch. Read more about this paper below:
Title
A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue
Abstract
Exposure to environmental stressors such as cigarette smoke (CS) elicits a variety of biological responses in humans, including the induction of inflammatory responses. These responses are especially pronounced in the lung, where pulmonary cells sit at the interface between the body’s internal and external environments. We combined a literature survey with a computational analysis of multiple transcriptomic data sets to construct a computable causal network model (the Inflammatory Process Network (IPN)) of the main pulmonary inflammatory processes. The IPN model predicted decreased epithelial cell barrier defenses and increased mucus hypersecretion in human bronchial epithelial cells, and an attenuated pro-inflammatory (M1) profile in alveolar macrophages following exposure to CS, consistent with prior results. The IPN provides a comprehensive framework of experimentally supported pathways related to CS-induced pulmonary inflammation. The IPN is freely available to the scientific community as a resource with broad applicability to study the pathogenesis of pulmonary disease.
Click here to learn more about the article, download it and comment
Posted in: Articles Published
News Categories
Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesWorking with Libertas Academica is a continuously great and exciting experience for me as Editor-in-Chief of Signal Transduction Insights. I feel that Libertas Academica offers creative publishing environment and professional, timely, individualized author service by competent and friendly staff. Libertas Academica attracts manuscripts of high quality and also provides high visibility for articles published. I will continue to work with Libertas Academica in the future and am happy to recommend publishing with Libertas Academica journals. ...
Facebook Google+ Twitter
Pinterest Tumblr YouTube