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Posted Thu, Jun, 13,2013
Published today in Retrovirology: Research and Treatment is a new review by Mqondisi Tshabalala, Gene D. Morse and Lynn S. Zijenah. Read more about this paper below:
Title
HLA Genetic Polymorphisms: Role in HIV-1 Susceptibility, Disease Progression and Treatment Outcomes
Abstract
The human leukocyte antigen (HLA) gene loci are key in human immunodeficiency virus (HIV) antigen presentation leading to an immune response to infection. The high genetic variation in these gene loci forms the basis of the host’s ability to mount immune responses to different viral epitopes. Polymorphisms of the HLA will impact susceptibility to HIV infection, disease progression, and treatment. This review aims at giving an overview on the role of HLA gene polymorphisms on HIV acquisition, rate of disease progression, and treatment outcomes. Understanding the HIV epitope-HLA complexes during infection might provide insight into the design of multi-epitope HIV vaccine for different populations.
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Interview with Professor Jamie DaviesRecently we have published a review on sRNA prediction in bacteria. Submission and processing is fast and very fair in Bioinformatics and Biology Insights. I have received emails at every stage of the review process until decision making. The experts' comments and suggestions has helped us to improve the manuscript. Because of the indexing and high visibility of the article in BBI we expect to receive a high number of citations. ...
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