Posted Fri, Jun, 07,2013
Published today in Clinical Medicine Insights: Oncology is a new review article by Miguel J. Gil-Gil, Carlos Mesia, Montserrat Rey and Jordi Bruna. Read more about this paper below:
Title
Bevacizumab for the Treatment of Glioblastoma
Abstract
Glioblastoma (GBM) or grade IV glioma is the most common primary brain tumor in adults. Standard treatment median overall survival (OS) is only 14–15 months and less than 10% of patients will survive 5 years after diagnosis. There is no standard treatment in recurrent GBM and OS ranges from 3 to 9 months. GBM is 1 of the most vascularized human tumors and GBM cells produce vascular endothelial growth factor (VEGF). Bevacizumab, a humanized monoclonal antibody against VEGF, has demonstrated activity in vitro and in phase II trials in relapse, as well as in 1 phase III trial as first line therapy. Bevacizumab also improves quality of life for patients suffering GBM. This paper reviews the mechanism of action of bevacizumab, its metabolism and pharmacokinetic profile. It summarizes the clinical studies in recurrent and newly diagnosed GBM, its potential side effects and complications and its place in therapy.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesMy experience with Libertas Academica was very positive from submission to acceptance. The reviewers' comments were very interesting and constructive. The author interface was user-friendly and very effective. The publishing process was fast and convenient. I recommend this journal.
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