Posted Mon, May, 20,2013
Published today in Bioinformatics and Biology Insights is a new short report by Pingzhao Hu, Aleixo M. Muise, Xiang Xing, John H. Brumell, Mark S. Silverberg and Wei Xu. Read more about this paper below:
Title
Association Between a Multi-Locus Genetic Risk Score and Inflammatory Bowel Disease
Abstract
To date, the utility of single genetic markers to improve disease risk assessment still explains only a small proportion of genetic variance for many complex diseases. This missing heritability may be explained by additional variants with weak effects. To discover and incorporate these additional genetic factors, statistical and computational methods must be evaluated and developed. We develop a multi-locus genetic risk score (GRS) based approach to analyze genes in NADPH oxidase complex which may result in susceptibility to development of inflammatory bowel disease (IBD). We find the complex is highly associated with IBD (P = 7.86 × 10−14) using the GRS-based association method. Similar results are also shown in permutation analysis (P = 6.65 × 10-11). Likelihood ratio test shows that the single nucleotide polymorphisms (SNPs) in the complex without nominal signals have significant contribution to the overall genetic effect within the complex (P = 0.015). Our results show that the multi-locus GRS association model can improve the genetic risk assessment on IBD by taking into account both confirmed and as yet unconfirmed disease susceptibility variants.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesThis was the most efficient and user-friendly publishing process I have experienced. The editorial team at Libertas Academica was phenomenal. They kept me engaged with each step of the publishing process and they were timely and professional with their response to my inquiries. I look forward to publishing additional articles with Libertas Academica in the future.
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