Posted Thu, May, 16,2013
Published today in Cancer Informatics is a new original research article by Chindo Hicks, Tejaswi Koganti, Alexandra S. Brown, Jesus Monico, Kandis Backus and Lucio Miele. Read more about this paper below:
Title
Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast CancerAbstract
Genome-wide association studies (GWAS) have achieved great success in identifying common variants associated with increased risk of developing breast cancer. However, GWAS do not typically provide information about the broader context in which genetic variants operate in different subtypes of breast cancer. The objective of this study was to determine whether genes containing single nucleotide polymorphisms (SNPs, herein called genetic variants) are associated with different subtypes of breast cancer. Additionally, we sought to identify gene regulator networks and biological pathways enriched for these genetic variants. Using supervised analysis, we identified 201 genes that were significantly associated with the six intrinsic subtypes of breast cancer. The results demonstrate that integrative genomics analysis is a powerful approach for linking GWAS information to distinct disease states and provide insights about the broader context in which genetic variants operate in different subtypes of breast cancer.
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Interview with Professor Jamie DaviesWorking with the Editor at the Journal of Medical Education and Curricular Development, and the publishing staff at Libertas Academica was an excellent experience. From submission to revision, the editorial process was smooth and fair. I had such a good experience that I will consider journals of Libertas Academica at the top of my list the next time I want to submit a manuscript.
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