Posted Tue, May, 07,2013
Published today in Lipid Insights is a new original research article by Kelsey D. Jordan and Rita K. Upmacis. Read more about this paper below:
Title
Mass Spectrometric Analysis of Oxidized Eicosapentaenoic Acid Sodium Salt
Abstract
Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid (PUFA) with 20 carbon atoms and 5 carbon-carbon double bonds. Mammalian cells cannot synthesize long chain PUFAs such as EPA de novo, and, thus, the most effective way to enrich cells in EPA is by dietary intake of fish oils. EPA supplementation causes an increase in its concentration in plasma lipids and in cell membrane phospholipids. Many beneficial effects of EPA supplementation have been noted, including (1) the potential to sensitize cancerous tumors towards chemotherapy, (2) the promotion of cardiovascular health, and (3) the alleviation of some mental disorders, but results from clinical trials have sometimes been disparate. In this study, we report the use of mass spectrometry to investigate the autoxidation of EPA, thereby demonstrating the formation of a variety of oxidized products. The oxidative stress of the patient may affect the response to EPA and may, in part, explain divergent results from clinical trials.
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Interview with Professor Jamie DaviesAs a peer reviewer for Environmental Health Insights, I have had the opportunity to read several very important research articles in my field. Based on my experience, the submission process, review standards, and publication expectations are rigorous and demanding as other high impact journals. I look forward to further reviewing papers for Environmental Health Insights and learning from my peers and other leaders in the field.
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