Posted Thu, Mar, 21,2013
Published today in Clinical Medicine Insights: Therapeutics is a new review by Monica A. Donnelley, Jeremiah J. Duby, and Christine S. Cocanour. Read more about this paper below:
Title
Safety and Efficacy of Fidaxomicin in Patients With Clostridium Difficile Infection
Abstract
Fidaxomicin is a bactericidal macrolide that is indicated for the treatment of Clostridium difficile infection (CDI) in adults. Fidaxomicin is not effective for the treatment of systemic infections due to minimal systemic absorption. Until recently, oral vancomycin was the only medication with United States Food and Drug Administration (FDA) approval for the treatment of CDI. In clinical studies, fidaxomicin demonstrated noninferiority to vancomycin for the treatment of CDI. Lower recurrence rates of CDI with fidaxomicin than with oral vancomycin were observed. The lower recurrence rates were not observed with highly virulent strains of C. difficile. Lower recurrence rates of CDI with fidaxomicin are believed to be associated with its narrow spectrum of activity. Fidaxomicin was approved for use after publication of the most recent guideline from the Society for Healthcare Epidemiology of America (SHEA) and Infectious Diseases Society of America (IDSA). However, its current place in clinical practice is unknown. The cost of fidaxomicin should be considered when prescribing this medication.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
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Interview with Professor Jamie DaviesThe review process in Libertas Academica journals is prompt, objective and rigorous. The entire process is smooth and clear and all the editorial staff are cooperative and professional. Published papers are of top clinical and scientific value, and high metrics reflect the excellent quality of Libertas Academica's journals.
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