Posted Thu, Mar, 07,2013
Published today in Clinical Medicine Insights: Oncology is a new original research article by Márcia A. Michelin, Douglas R. Abdalla, André A.R. Aleixo and Eddie F.C. Murta. Read more about this paper below:
Title
Peripheral Helper Lymphocytes Produce Interleukin 12 in Cancer Patients
Abstract
The aim of the study was to seek evidence for the production of IL-12 by CD4+ T lymphocytes in in vitro and ex vivo trials. We performed in vitro trials with spleen cells from mice subjected to carcinogenesis, as well as ex vivo trials with cells obtained from the peripheral blood of healthy individuals and cancer patients. We were able to verify a significantly increased expression of IL-12 in CD4+ T lymphocytes from mice and patients with tumors, compared to controls. Follow-up studies are needed to clarify whether this difference is related to being in a chronic disease state or whether it is an attempt by the immune system to produce an anti-tumor response, since T lymphocytes from healthy donors were not able to produce IL-12 when in contact with polyclonal stimuli. We concluded that, in cancer, T helper cells are capable of synthesizing IL-12, raising the question of whether we are faced with another profile, Th12.
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Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesMy experience with Libertas Academica was very positive from submission to acceptance. The reviewers' comments were very interesting and constructive. The author interface was user-friendly and very effective. The publishing process was fast and convenient. I recommend this journal.
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