Posted Tue, Feb, 19,2013
Published today in Cancer Growth and Metastasis is a new perspective article by Carlos M. Telleria. Read more about this paper below:
Title
Repopulation of Ovarian Cancer Cells After Chemotherapy
Abstract
The high mortality rate caused by ovarian cancer has not changed for the past thirty years. Although most patients diagnosed with this disease respond to cytoreductive surgery and platinum-based chemotherapy and undergo remission, foci of cells almost always escape therapy, manage to survive, and acquire the capacity to repopulate the tumor. Repopulation of ovarian cancer cells that escape front-line chemotherapy, however, is a poorly understood phenomenon. Here I analyze cancer-initiating cells, transitory senescence, reverse ploidy, and cellular dormancy as putative players in ovarian cancer cell repopulation. As part of the standard of care, ovarian cancer patients do not receive treatment between primary cytotoxic therapy and clinical relapse. Understanding the mechanisms driving cellular escape from chemotherapy should lead to the development of low toxicity, chronic treatment approaches that can be initiated right after primary therapy to interrupt cell repopulation and disease relapse by keeping it dormant and, therefore, subclinical.
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Interview with Professor Jamie DaviesContributing an invited review was a pleasant experience with Libertas. We are grateful for such a solid platform and their belief in young talented scientists and their research. Overall, it was a wonderful and simplified process from submission to publication of the article with regular updates at each step from various staff members. Each person was extremely efficient and very professional during manuscript processing.
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