Posted Thu, Feb, 14,2013
Published today in Clinical Medicine Insights: Case Reports is a new case report by Mariko Sue, Aya Yoshihara, Koji Kuboki, Naoki Hiroi and Gen Yoshino. Read more about this paper below:
Title
A Case of Severe Acute Necrotizing Pancreatitis after Administration of Sitagliptin
Abstract
A 55-year-old Japanese man with a 3-year history of type 2 diabetes mellitus was admitted to our hospital for upper abdominal pain. Control of diabetes mellitus was good with voglibose and metformin, with sitagliptin added to this regimen 8 months prior. His pancreatic enzyme levels were elevated, and abdominal computed tomography (CT) showed diffuse pancreatic swelling with fluid accumulation and ascites of CT grade 3. The patient was diagnosed with severe acute pancreatitis. There were no obvious causes for pancreatitis except the recently administered sitagliptin. Since incretin-related drugs entered the market, the number of incretin-related drugs prescriptions rapidly increased and so did the incidence of pancreatitis. There are several reports suggesting the correlation between incretin-related drugs and pancreatitis, such as a report based on data obtained from the United States Food and Drug Administration (FDA) which revealed a significant correlation between the administration of exenatide or sitagliptin and pancreatitis. However, there also is a report that denied the evidence for such in a large cohort study. The relation between incretin based drugs and pancreatitis is still controversial.
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Thu 08 Oct, 2015
Published This Week (5th - 9th October)Thu 08 Oct, 2015
Biomarker Insights Paper Endorsed by Editor in ChiefWed 07 Oct, 2015
Interview with Professor Jamie DaviesThank you very much for the positive learning experience in publishing with you. It has been a wonderful experience from submission to final acceptance and publication in the International Journal of Insect Science. We are grateful to the editorial team for developing our manuscript into a valuable scientific paper through a well-formulated and quick reviews. The team was dedicated, quick and always available to respond positively to our demands. We are also thankful for the ...
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