This interview is with Biomarker Insights editorial board member Dr Paul Lampe. Biomarker Insights is an open access journal published by Libertas Academica.

Editor in Chief Dr Stephen F Kingsmore has recently issued a call for papers.

What is the primary focus of your work and main areas of expertise?

Early detection and diagnostic cancer-related biomarkers.

What are the most exciting and cutting-edge developments in your area?

Proteomics using large format protein arrays - antibody, recombinant antibody, tissue lysate or proteome arrays.

Who are your main formal and informal collaborators and/or networks? Please describe your work with them.

The Fred Hutchinson Cancer Research Center facilitates extensive interactions between laboratory scientists, clinicians, epidemiologists and biostatisticians and we collaborate with several networks including the Early Detection Research Network (NCI-NIH) and the Women's Health Initiative (NHLBI/NIH) to name a few.

How did you come to be working in your research area?

My laboratory investigates the control of cell growth both at the cell biological/ mechanistic level and through cancer biomarker discovery. Our interest in gap junctions as potential biomarkers of cancer and, more recently, the advent of new screening methodologies has expanded our efforts into broad proteomic screens for potential cancer biomarkers using mass spectrometry and recombinant/full length antibody array technologies.

What do you think about the development of open access publishing? Have you published in an open access journal? What motivated you to do so?

Given pressures from funding sources, budget restrictions, and endorsements from many of the world's leading scientists, open access publishing seems destined to continue to grow.

What articles and/or books have you published recently?

Recent Biomarker related articles:

1. McTiernan, A., Yasui, Y., Sorensen, B., Irwin, M.L., Morgan, A., Rudolph, R.E. Surawicz, C., Lampe, J.W. Ayub, K., Potter, J.D., Lampe, P.D. “Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial” (2006) Cancer Epidemiol. Biomarkers Prev. 15, 1588-1597.
2. Gafken, P.R., Lampe, P.D. “Methodologies for Characterizing Phosphoproteins by Mass Spectrometry” (2006) Cell Commun. Adhes. 13, 249-262.
3. McTiernan, A., Sorensen, B., Irwin, M.L., Morgan, A., Yasui, Y., Rudolph, R.E., Surawicz, C., Lampe, J.W., Lampe, P.D., Ayub, K., Potter, J.D. “Exercise effect on weight and body fat in men and women” (2007) Obesity, 15, 1496-512.
4. Campbell, K.L, McTiernan, A., Li, S.S, Sorensen, B.E, Yasui, Y., Lampe, J.W, King, I.B., Ulrich, C.M, Rudolph, R.E., Irwin, M.L., Surawicz, C., Ayub, K., Potter, J.D., Lampe, P.D. Effect of a 12-month exercise intervention on Bax, Bcl-2 and apoptosis in colon crypts: A randomized controlled trial. (2007) Cancer Epidemiol. Biomarkers Prev, 16,1767-74.
5. Abrahamson PE, King IB, Ulrich CM, Rudolph RE, Irwin M.L., Yasui Y., Surawicz C., Lampe J.W., Lampe P.D., Morgan A, Sorensen BE, Ayub K, Potter JD, McTiernan A. No effect of exercise on colon mucosal prostaglandin concentrations: a 12-month randomized controlled trial. (2007) Cancer Epidemiol Biomarkers Prev. 16, 2351-6 6.
   
6. Loch, C.M., Ramirez, A.B., Liu, Y., Sather, C.L., Delrow, J.J., Scholler, N., Garvik, B.M., Urban, N.D., McIntosh, M.W., and Lampe, P.D. “Use of High Density Antibody Arrays to Validate and Discover Cancer Serum Biomarkers.” (2007) Molecular Oncology, 1, 313-320.
7. Adewale, A. Liu, Q., Dinu, I., Lampe, P.D. , Mitchell, B.L., Yasui, Y. “A Cautionary Note on the Evaluation of Biomarkers of Subtypes of a Single Disease” (2008) Amer. J. Epidemiol. 68(6), 559-62.
8. Scholler, N., Gross, J.A., Garvik, B., Wells, L., Liu, Y., Loch, C.M., Ramirez, A.B., McIntosh, M.M., Lampe, P.D., Urban, N. Use of cancer-specific yeast-secreted in vivo biotinylated recombinant antibodies for serum biomarker discovery” (2008) J Transl. Med. 6, 41.

Further information about Dr Lampe:

• Dr Lampe's lab
  
  
• COS profile
  
  
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