Close
Help




JOURNAL

Gene Expression to Genetical Genomics

Is Glycogen Synthase Kinase-3β an Ultraconserved Kernel Enzyme?

Submit a Paper


Gene Expression to Genetical Genomics 2009:2 1-27

Review

Published on 11 Dec 2009


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Gene Expression to Genetical Genomics

Abstract

Glycogen synthase kinase 3β (GSK3β) was discovered as a major factor in glucose homeostasis. GSK3β is a pivotal regulator of glycogen synthesis by altering the activity of glycogen synthase and perturbation in this process have been linked to at least some sub-entities of insulin resistance and diabetes mellitus. However, GSK3β has a central role in many biochemical and physiological processes apparently not related to insulin resistance or diabetes. The functionality of GSK3β is vast including more than 33 substrates and 72 protein-protein interactions, and is involved in such diverse diseases as cancer, schizophrenia, inflamation, cardiac diseases and many more. Considering this scale of the involvement of GSK3β, many related to developmental processes, suggests that either is GSK3β a high-level network-hub or is a peripheral kinase in several non-connected networks. Here, evidence is provided that GSK3β is an ultraconserved protein which would suggest that the enzyme qualify to be a kernel protein in the sense that life as we know it depends on conserved molecular entities to provide the essential functionality to an organism. The enzyme has evolved under strong purifying selection implicating that GSK3β is a functional hub.



Downloads

PDF  (797.48 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)


Sharing


What Your Colleagues Say About Libertas Academica
This is the fastest progress we have experienced from submission to acceptance.  Reviews are fast, pertinent, and instructive.  Every step of the process is visible and prompt, and every email is friendly and immediate.  In all, it is an excellent experience to be published in Libertas Academica.
Dr Jiang Wang (Sun Yat sen University, Guangzhou, P.R. China.)
More Testimonials

Quick Links


New article and journal news notification services
Email Alerts RSS Feeds
Facebook Google+ Twitter
Pinterest Tumblr YouTube