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Clinical Medicine: Pediatrics

Synopsis: An open access, peer reviewed electronic journal that covers diagnosis, management and prevention of conditions specific to childhood and adolescents.


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About this journal

ISSN: 1178-220X


Aims and scope:

Clinical Medicine: Pediatrics is an international, open access, peer reviewed journal which considers manuscripts on all aspects of the diagnosis, management and prevention of disorders specific to children and adolescents, in addition to related genetic, pathophysiological and epidemiological topics.

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Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

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As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

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INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months

Authors: Ann Chen Wu, Matthew W. Gillman, Elsie M. Taveras and Augusto A. Litonjua
Publication Date: 18 Feb 2009
Clinical Medicine: Pediatrics 2009:3 33-37

Ann Chen Wu1,2, Matthew W. Gillman1,3, Elsie M. Taveras1,2 and Augusto A. Litonjua4-6

1Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts, U.S.A. 2Division of General Pediatrics, Children’s Hospital, Boston, Massachusetts, U.S.A. 3Department of Nutrition, Harvard School of Public Health, Massachusetts, U.S.A. 4Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital. 5Harvard Medical School, Boston, Massachusetts, U.S.A. 6Center for Genomic Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, U.S.A.

Abstract

Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11–60 years.1  To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.

Categories: Pediatrics


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