Gene Regulation and Systems Biology

Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats

Submit a Paper

Gene Regulation and Systems Biology 2015:9 15-26

Original Research

Published on 10 Aug 2015

DOI: 10.4137/GRSB.S25172

Further metadata provided in PDF

Sign up for email alerts to receive notifications of new articles published in Gene Regulation and Systems Biology


Development and progression of type 2 diabetes is a complex interaction between genetics and environmental influences. High dietary fat is one environmental factor that is conducive to the development of insulin-resistant diabetes. In the present report, we compare the responses of lean polygenic, diabetic Goto-Kakizaki (GK) rats to those of control Wistar-Kyoto (WKY) rats fed a high fat diet from weaning to 20 weeks of age. This comparison included a wide array of physiological measurements along with gene expression profiling of abdominal adipose tissue using Affymetrix gene array chips. Animals of both strains fed a high fat diet or a normal diet were sacrificed at 4, 8, 12, 16, and 20 weeks for this comparison. The microarray analysis revealed that the two strains developed different adaptations to increased dietary fat. WKY rats decrease fatty acid synthesis and lipogenic processes whereas GK rats increase lipid elimination. However, on both diets the major differences between the two strains remained essentially the same. Specifically relative to the WKY strain, the GK strain showed lipoatrophy, chronic inflammation, and insulin resistance.




Supplementary Files 1  (221.66 KB ZIP FORMAT)

BibTex citation   (BIBDESK, LATEX)


What Your Colleagues Say About Gene Regulation and Systems Biology
Since my first enquiry about publishing in Gene Regulation And Systems Biology until the last moment of completing all the steps for publishing my paper, I was always taken seriously as author.  All my questions and concerns were answered in a very professional way.  The review process was quick and very fair.  Reviewers stick to the facts and declare their points of view like a clear thread through the manuscript.  I always had an enthusiastic ...
Dr Jasmine Kharazmi (University of Zurich, Irchel, Zurich, Switzerland)
More Testimonials

Quick Links

New article and journal news notification services
Email Alerts RSS Feeds
Facebook Google+ Twitter
Pinterest Tumblr YouTube