Magnetic Resonance Insights

Detection of Amide and Aromatic Proton Resonances of Human Brain Metabolites Using Localized Correlated Spectroscopy Combined with Two Different Water Suppression Schemes

Submit a Paper

Magnetic Resonance Insights 2010:4 1-9

Original Research

Published on 15 Jun 2010

DOI: 10.4137/MRI.S4739

Further metadata provided in PDF

Sign up for email alerts to receive notifications of new articles published in Magnetic Resonance Insights


The purpose of the study was to demonstrate the J-coupling connectivity network between the amide, aliphatic, and aromatic proton resonances of metabolites in human brain using two-dimensional (2D) localized correlated spectroscopy (L-COSY). Two different global water suppression techniques were combined with L-COSY, one before and another after localizing the volume of interest (VOI). Phantom solutions containing several cerebral metabolites at physiological concentrations were evaluated initially for sequence optimization. Nine healthy volunteers were scanned using a 3T whole body MRI scanner. The VOI for 2D L-COSY was placed in the right occipital white/gray matter region. The 2D cross and diagonal peak volumes were measured for several metabolites such as N-acetyl aspartate (NAA), creatine (Cr), free choline (Ch), glutamate/glutamine (Glx), aspartate (Asp), myo-inositol (mI), GABA, glutathione (GSH), phosphocholine (PCh), phosphoethanolamine (PE), tyrosine (Tyr), lactate (Lac), macromolecules (MM) and homocarnosine (Car). Using the pre-water suppression technique with L-COSY, the above mentioned metabolites were clearly identifiable and the relative ratios of metabolites were calculated. In addition to detecting multitude of aliphatic resonances in the high field region, we have demonstrated that the amide and aromatic resonances can also be detected using 2D L-COSY by pre water suppression more reliably than the post-water suppression.




BibTex citation   (BIBDESK, LATEX)


What Your Colleagues Say About Magnetic Resonance Insights
It was a pleasure to work with your editorial board.  Responses were extremely rapid and very useful.  You must be the most e-literate journal with which I have interacted, and that is many, including the big guys.  I am proud to have our  review published in Magnetic Resonance Insights.
Dr Ian CP Smith (Innovative Biodiagnostics Inc., Winnipeg, Canada)
More Testimonials

Quick Links

New article and journal news notification services
Email Alerts RSS Feeds
Facebook Google+ Twitter
Pinterest Tumblr YouTube