Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test

Benoît Dupont; Delphine Mariotte; Cristian Moldovan; Jean-Michel Grellard; Marie-Claude Vergnaud; Dominique Laroche; Radj Gervais

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Clinical Medicine Insights: Oncology

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Case Report About Fatal or Near-Fatal Hypersensitivity Reactions to Cetuximab: Anticetuximab IgE as a Valuable Screening Test

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Authors: Benoît Dupont, Delphine Mariotte, Cristian Moldovan, Jean-Michel Grellard, Marie-Claude Vergnaud, Dominique Laroche and Radj Gervais

Publication Date: 22 Jul 2014

Type: Case report

Journal: Clinical Medicine Insights: Oncology

Citation: Clinical Medicine Insights: Oncology 2014:8 91-94

doi: 10.4137/CMO.S13897

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Abstract

Hypersensitivity reactions are a classic side effect of cetuximab. We report the cases of three patients who developed life-threatening hypersensitivity to cetuximab, which could have been predicted by assessing the concentration of serum anticetuximab immunoglobulin (Ig)E. The anticetuximab IgE concentration could be an interesting test to predict which patients are at risk of experiencing severe hypersensitivity reactions to cetuximab.

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