Close
Help




JOURNAL

Proteomics Insights

A Survey of Membrane Proteins in Human Serum

Submit a Paper


Proteomics Insights 2012:5 1-19

Original Research

Published on 03 Apr 2012

DOI: 10.4137/PRI.S9374


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Proteomics Insights

Abstract

Serum and membrane proteins are two of the most attractive targets for proteomic analysis. Previous membrane protein studies tend to focus on tissue sample, while membrane protein studies in serum are still limited. In this study, an analysis of membrane proteins in normal human serum was carried out. Nano-liquid chromatography-electrospray ionization mass spectrometry (NanoLC-ESI-MS/MS) and bioinformatics tools were used to identify membrane proteins. Two hundred and seventeen membrane proteins were detected in the human serum, of which 129 membrane proteins have at least one transmembrane domain (TMD). Further characterizations of identified membrane proteins including their subcellular distributions, molecular weights, post translational modifications, transmembrane domains and average of hydrophobicity, were also implemented. Our results showed the potential of membrane proteins in serum for diagnosis and treatment of diseases.



Downloads

PDF  (752.84 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)

XML

PMC HTML


Sharing


What Your Colleagues Say About Proteomics Insights
testimonial_image
I have published more than thirty research papers in internationally reputed high impact factor journals including Libertas Academica publications, Proteomics Insights and Analytical Chemistry Insights. I have no hesitation in saying that Proteomics Insights is highly efficient for its rapid and high quality review process and keeping the authors informed at each stage of the publication process. I recommend this journal for students, teachers and research workers who wish to publish their work. ...
Dr M V Jagannadham (Centre for Cellular and Molecular Biology, Hyderbad, India)
More Testimonials

Quick Links


New article and journal news notification services
Email Alerts RSS Feeds
Facebook Google+ Twitter
Pinterest Tumblr YouTube