Close
Help




JOURNAL

Advances in Tumor Virology

Tumor Cell Development: A Role for Viruses and Telomerase Activity?

Submit a Paper


Advances in Tumor Virology 2014:4 7-16

Review

Published on 22 Jul 2014

DOI: 10.4137/ATV.S12440


Further metadata provided in PDF



Sign up for email alerts to receive notifications of new articles published in Advances in Tumor Virology

Abstract

Telomere biology is an important aspect of human cancer, because the telomere dysfunction and telomerase activity are associated with genomic instability and cellular immortalization. In this article, we review the regulation of telomere dynamics and telomerase activity in virus-related cancers. Viruses may exploit these events to favor its replication and, therefore, may differ from non-viral cancers in this regard. Focusing on Epstein–Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), and hepatitis C virus (HCV), which concentrate the majority of the evidence regarding telomere biology and viral cancers), although other viruses are more briefly mentioned, it is noticeable that regulatory mechanisms of telomere dynamics and telomerase activity are virus specific. Such mechanisms include accelerated telomere shortening because of higher rates of cellular proliferation, telomerase activity regulation, and activation of alternative lengthening of telomeres (ALT). Additionally, there is also some evidence supporting a role of viral non-coding RNAs (ncRNAs) and virus-induced alterations in host ncRNAs in telomerase activity. Clarification of the roles of telomere biology in mediating viral cancers would have implications only for developing telomere-targeting anti-cancer approaches and, possibly, to accelerate advances in other telomere-related diseases, such as non-viral cancers and other aging traits.



Downloads

PDF  (832.30 KB PDF FORMAT)

RIS citation   (ENDNOTE, REFERENCE MANAGER, PROCITE, REFWORKS)

BibTex citation   (BIBDESK, LATEX)


Sharing


What Your Colleagues Say About Advances in Tumor Virology
I was delighted to submit an invited review on cluster headache pharmacology.  As someone who writes a few papers per year on these subjects, I appreciated that the submission, review and approval process for the paper was smooth and efficient. Our reviewers raised important points that improved the overall quality of the manuscript. Overall a very positive experience.
Dr Michael J. Marmura (Thomas Jefferson University, Philadelphia, PA, USA)
More Testimonials

Quick Links


New article and journal news notification services
Email Alerts RSS Feeds
Facebook Google+ Twitter
Pinterest Tumblr YouTube