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Clinical Medicine Insights: Blood Disorders

Ribosomopathies: Mechanisms of Disease

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Clinical Medicine Insights: Blood Disorders 2014:7 7-16

Review

Published on 14 Aug 2014

DOI: 10.4137/CMBD.S16952


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Abstract

Ribosomopathies are diseases caused by alterations in the structure or function of ribosomal components. Progress in our understanding of the role of the ribosome in translational and transcriptional regulation has clarified the mechanisms of the ribosomopathies and the relationship between ribosomal dysfunction and other diseases, especially cancer. This review aims to discuss these topics with updated information.



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