Roger J. Lins and Murray D. Mitchell

National Research Centre for Growth and Development and The Liggins Institute, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

Abstract

The appropriate modulation of gene expression in gestational tissues is an essential requirement for a successful pregnancy. Epigenetic control of gene expression through the reversible modification of chromatin has emerged as a fundamental mechanism for the coordination of gene expression in a range of biological systems. Here we summarize recent results in support of our hypothesis that key physiological events and pathological processes occurring throughout human pregnancy are under epigenetic control.