Clinical Medicine Insights: Case Reports

The best characterized disorder of REM sleep, narcolepsy has never previously been associated with Duane’s syndrome, in which there is developmental failure of the abducens nerve and its nucleus. The major brain stem nuclei responsible for REM sleep generation are situated in the pons in close proximity to the abducens nerve nucleus. We report the novel combination of Duane’s syndrome and narcolepsy, providing new insight into the pathogenesis of narcolepsy.