Tell us about where you work.  What do you do there, and who do you work with?

I work at the Jawaharalal Nehru University in New Delhi, India. I have worked as Professor and Dean of the school of Computational & Integrative Sciences for the last 4 years, it has 10 faculties, 20 Ph.D research fellows and Mtech course on Computational & systems Biology.

What are your primary areas of research?  What do you aim to achieve in these areas?

Computational Biology, Biophysics, Bioinformatics, pathogenesis of disease, design of chemicals & systems biology approach to disease.

What contributions have you made to these areas so far?  What is the broader importance of your contributions?

The first contribution was during my PhD to develop a new method for inhibitor docking at the active site of a metallo protease published in 1982, the next method was to calculate free energy perturbation in protein in solvent published in 1984 and many papers on molecular simulations. In bioinformatics ANN method to predict promoters in 1994, molecular modelling of plasmodium drug targets proteins in 2005, anti-tuberculosis chemical design in 2006, identification of pathway for tuberculosis metabolism using kinetic modelling in 2007 and recently mapping the protein using fractal dimension in 2010.

What directions do you expect your research in these areas to take in the future?

Presently I am interested and working in systems approach to simulation and modelling in cellular environment.

What do you consider to be the most important recent developments in your areas of research?

I consider target mapping using systems biology, cellular functioning, dynamics at the macromolecular level and probing biology using small molecules the most important recent developments in my area of research.

 Visit Professor Ghosh's web page

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