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Virology: Research and Treatment

Synopsis: An open access, peer reviewed electronic journal that covers all aspects of virus research and treatment in humans, animals, plants, bacteria and fungi.


Indexing: 4 major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 600+ times.

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About this journal

Aims and scope:

Virology: Research and Treatment is an international, open access, peer reviewed journal which considers manuscripts on all aspects of viruses. All articles on human, animal, insect, plant, and bacterial and fungal viruses are considered.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

Indexing:

This journal is indexed by the following services:

  • Google Scholar
  • CAS
  • DOAJ
  • SCOPUS

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 

ISSN: 1178-122X


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Generation of BKV-Specific T Cells for Adoptive Therapy Against BKV Nephropathy

Authors: Jongming Li, Bijoyesh Mookerjee, Priya Singh and John L Wagner
Publication Date: 02 Dec 2008
Virology: Research and Treatment 2008:1 97-107

Jongming Li1, Bijoyesh Mookerjee2, Priya Singh1 and John L Wagner1

1Department of Medical Oncology, 1024 Curtis Building, Thomas Jefferson University, 1015 Walnut St., Philadelphia, PA, U.S.A., 19107. 21800 Concord Pike, AstraZeneca PLC, Wilmington, DE 19850–5437.

Abstract

Nephropathy associated with BK virus has emerged as an important cause of allograft failure in renal transplant recipients. Here we exploited a recently developed novel monocyte based solid phase T cell selection system, in which monocytes are immobilized on solid support, for antigen-specific T cell purification. The underlying hypothesis of this new method is that antigen-specific T cells recognize, bind their cognate antigens faster than non-specific T cells and are concentrated on the surface after removing the non-adherent cells by washing. Moreover, activated antigen-specific T cells proliferate more rapidly than non-specific T cells, further increasing the frequency and purity of antigen-specific T cells. Optimal selection times for BK virus-specific T cells are studied. Our data demonstrated that T cell selection can usually increase the frequency of antigen-specific T cells by   10 fold, whereas T cell expansion following the selection boost the frequency of antigen-specific T cells by another ~10 fold. This new T cell selection system is superior to traditional stimulation method (i.e. simply mixing antigen presenting cells and lymphocytes together) in generating antigen-specific T cells. This inexpensive and simple T cell selection system can produce large quantity of highly purified BK virus-specific T cells within 1–2 weeks after initial T cell activation.

Categories: Virology


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