Clinical Medicine Reviews in Vascular Health

Hypertension and hypercholesterolemia are two of the main causes of disease burden worldwide. Both conditions are related, and the prevalence of hypercholesterolemia is higher in hypertensive patients and vice versa. Current guidelines agree that the aim of treatment should not only be to control just one risk factor, but to reduce overall cardiovascular risk through a multifactorial intervention, treating all risk factors and conditions as associated. Nevertheless, current control rates are far from optimal. The combination of amlodipine and atorvastatin has been shown to effectively reduce both blood pressure and LDL-cholesterol levels with a good tolerability profile. This in turn has led to a more intense reduction in coronary events than with other regimens, as observed in the ASCOT trial. Furthermore, simplification of treatment can improve adherence. In this context, fixed combinations help to achieve this goal. This paper updates published data on the combination of amlodipine and atorvastatin.