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Bioinformatics and Biology Insights

Synopsis: An open access, peer reviewed electronic journal that covers computational biology, particularly computational methods used in the analysis and annotation of structures.


Indexing: 6 major databases. Pubmed indexing for NIH-funded research.

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About this journal

Aims and scope:

Bioinformatics and Biology Insights is an open access, peer-reviewed journal that considers articles on computational methods used in the analysis and annotation of structures, in addition to other areas of computational biology and the broader field of biology.

It both complements Libertas Academica’s subject-specific journals in the area and also seeks to place bioinformatics in the broader context of biology. The journal welcomes all submissions in the field of bioinformatics and also submissions dealing with the relationship between bioinformatics and the broader field of biology. Submissions of original research, reviews, tutorials, rapid communications, expert commentaries, letters, application notes, and point–counter-point articles are welcomed for peer review. No word limits are imposed, but authors are reminded that excessive word-counts may attract adverse comment by peer reviewers and discourage readers.

The submission of tutorial-type articles is encouraged, in which methods which have been developed in the recent past are reviewed in such a way as to make them readily comprehensible for Biologists. Papers discussing methodologies are discouraged unless they explicitly demonstrate that new biological insights have been gained or that earlier methods used to gain a new insight can be replaced.

Authors are encouraged to consider submitting their manuscripts to Evolutionary Bioinformatics and Cancer Informatics, if they consider that their manuscript is exclusively or specifically relevant to those journals’ audiences.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

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This journal is indexed by the following services:

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SPARC Europe Seal award winner:

This journal has been awarded a SPARC Europe Seal. The Seal is an initiative of SPARC Europe (Scholarly Publishing and Academic Resources Coalition) and the Directory of Open Access Journals (DOAJ) which is awarded to journals applying a Creative Commons CC-BY copyright license and that make journal metadata accessible to DOAJ.  

 Amongst other important services DOAJ makes metadata OAI-compliant.  This in turn enhances the visibility of papers and allows OAI-harvesters to include the details of journal articles in their services. We encourage readers to make use of this valuable resource.  The DOAJ search page is available here.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 

ISSN: 1177-9322


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Effects of Feeding Periods of High Cholesterol and Saturated Fat Diet on Blood Biochemistry and Hydroxyproline Fractions in Rabbits

Authors: Mohamed A. K. Abdelhalim, N. J. Siddiqi, A. S. ALhomida and Mohammed S. Al- Ayed
Publication Date: 22 Apr 2008
Bioinformatics and Biology Insights 2008:2 239-244

Mohamed A.K. Abdelhalim1, N.J. Siiddiqi2, A.S. ALhomida2 and Mohammed S. Al-Ayed1

1King Saud University, College of Science, Department of Physics and Astronomy, Biomedical Science Group, Riyadh, Saudi Arabia. 2King Saud University, College of Science, Department of Biochemistry, Riyadh, Saudi Arabia.

Abstract

Hypercholesterolemia and hypertriglyceridemia are considered as important risk factors during the atherosclerotic process. The aim of the present investigation was to study the total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), high density lipoprotein (HDL), triglyceride (TG), platelet levels and hydroxyproline fractions during the pathogenesis of atherosclerosis. For this purpose, twenty five 12-weeks, New Zealand white male rabbits, were purchased, individually caged, and divided into either control group or cholesterol-fed group. The control group (n = 10) was fed 100 g/day of normal diet, ORC-4 (Oriental Yeast Co. Ltd., Tokyo, Japan) for a period of 15 weeks. The cholesterol-fed group (n = 15) was fed a high cholesterol and saturated fat diet of ORC-4 containing 1% cholesterol plus 1% olive oil (100 g/day) for periods of 5 (group 1), 10 (group 2) and 15 (group 3) weeks. Blood sample from each animal was taken at the end of the experimental period for the biochemical analysis. The results of the present study showed that TC, LDLC, TG, HDLC and platelets were significantly (P<0.01) increased in cholesterol-fed rabbits as compared with control rabbits. The serum hydroxyproline (Hyp) in rabbits belonging to group 1 showed no significant alteration when compared to control group. Group 2 rabbits showed a significant increase of 103% (P<0.01) and 100% (P<0.001) in free and protein—bound hydroxyproline fractions respectively when compared to control rabbits. However, there was no significant change in peptide—bound and total serum hydroxyproline levels as compared to the control group (P>0.05). There was no significant (P>0.05) decrease of free serum hydroxyproline in group 3 rabbits when compared to control rabbits. On the other hand, group 3 rabbits showed a significant increase in peptide–bound and protein- bound Hyp by 517% (P<0.05) and 100% (P<0.01) respectively when compared to control rabbits. However, total serum Hyp in group 3 rabbits showed no significant (P>0.05) change when compared to control rabbits. These results suggest that feeding rabbits high cholesterol and saturated fat diet for feeding periods of 5 , 10 and 15 weeks induced significant change in TC, LDLC, HDL, TG, platelet levels and various Hyp fractions in serum without any significant change in the total Hyp content.

Categories: Bioinformatics


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