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Journal of Brain Disease

Synopsis: An open access, peer reviewed electronic journal that covers human brain diseases and disorders.


Indexing: Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

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About this journal

Aims and scope:

Journal of Brain Disease is an open access, peer-reviewed journal which covers all types of human brain diseases and disorders.  Clinical practice, research, and education of brain disease science are emphasized. Adult and pediatric neurology, neurosurgery, neuroradiology, endovascular surgical neuroradiology, neuropsychiatry, neurophysiatry, neuropharmacology, neurophysiology, and neuropathology specialties are represented. 

Manuscripts on epidemiology, pathology, diagnosis, prognosis, and management of all brain diseases are welcomed.

Editorial standards and procedures:

Submissions, excluding editorials, letters to the editor and dedications, will be peer reviewed by two reviewers.  Reviewers are required to provide fair, balanced and constructive reports.  

Under our Fairness in Peer Review Policy authors may appeal against reviewers' recommendations which are ill-founded, unobjective or unfair.  Appeals are considered by the Editor in Chief or Associate Editor.

Papers are not sent to peer reviewers following submission of a revised manuscript. Editorial decisions on re-submitted papers are based on the author's response to the initial peer review report.

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 

 


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Yi-Gan San Restores Behavioral Alterations and a Decrease of Brain Glutathione Level in a Mouse Model of Schizophrenia

Authors: Manabu Makinodan, Takahira Yamauchi, Kouko Tatsumi, Hiroaki Okuda, Yoshinobu Noriyama, Miyuki Sadamatsu, Toshifumi Kishimoto and Akio Wanaka
Publication Date: 12 Feb 2009
Journal of Brain Disease 2009:1 1-6

Manabu Makinodan1, Takahira Yamauchi1, Kouko Tatsumi2, Hiroaki Okuda2, Yoshinobu Noriyama1, Miyuki Sadamatsu1, Toshifumi Kishimoto1 and Akio Wanaka2

1Department of Psychiatry and 2Department of Anatomy and Neuroscience, Nara Medical University Faculty of Medicine.

Abstract

The traditional Chinese herbal medicine yi-gan san has been used to cure neuropsychological disorders. Schizophrenia can be one of the target diseases of yi-gan san. We aimed at evaluating the possible use of yi-gan san in improving the schizophrenic symptoms of an animal model. Yi-gan san or distilled water was administered to mice born from pregnant mice injected with polyinosinic-polycytidilic acid or phosphate buffered saline. The former is a model of schizophrenia based on the epidemiological data that maternal infection leads to psychotic disorders including schizophrenia in the offspring. Prepulse inhibition and sensitivity to methamphetamine in open field tests were analyzed and the total glutathione content of whole brains was measured. Yi-gan san reversed the decrease in prepulse inhibition, hypersensitivity to methamphetamine and cognitive deficits found in the model mice to the level of control mice. Total glutathione content in whole brains was reduced in the model mice but was restored to normal levels by yi-gan san treatment. These results suggest that yi-gan san may have ameliorating effects on the pathological symptoms of schizophrenia.



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