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International Journal of Tryptophan Research

Synopsis: An open access, peer reviewed electronic journal that covers tryptophan and associated neurological processes.


Indexing: Two major databases. Pubmed indexing for NIH-funded research.

Processing time: Decision in 2 weeks for 90% of papers.

Visibility: Most popular article read 190+ times.

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About this journal

ISSN: 1178-6469


Aims and scope:

The International Journal of Tryptophan Research is an international, open access, peer reviewed journal which covers all subjects related to Tryptophan research. There is no suitable journal that focuses on Tryptophan, and the IJTR aims to fill this void and provide a forum for those with interests in this area.

The journal also covers related precursors and metabolites such as serotonin, melatonin, niacin, tryptamine, kynurenine, and indoleamine 2,3-dioxygenase. Topics include isolation, functionality, interactions, analysis, synthesis and industrial production, as well as supplementation and role in diet, physiology, neurological disorders and immune response. However all articles related to Tryptophan are welcome.

Editorial standards and procedures:

All submissions to this journal, with the exception of editorials and dedications (obituaries), are subject to rigorous peer review by a minimum of two peer reviewers who demonstrate current research experience in the paper's subject area.  Reviewers are required to provide in-depth, fair and objective reviews.  They may not act as reviewers if they are in a conflict of interest.  All final publishing decisions are made by the Editor in Chief or Associate Editor.

Indexing:

This journal is indexed by:

  • CAS
  • DOAJ

National Institutes of Health Public Access Policy compliant:

As of April 7 2008, the US NIH Public Access Policy requires that all peer reviewed articles resulting from research carried out with NIH funding be deposited in the Pubmed Central archive.

If you are an NIH employee or grantee Libertas Academica will ensure that you comply with the policy by depositing your paper at Pubmed Central on your behalf. 



 
 
 


Production and Peripheral Roles of 5-HTP, a Precursor of Serotonin

Authors: Kazuhiro Nakamura and Hiroyuki Hasegawa
Publication Date: 30 Mar 2009
International Journal of Tryptophan Research 2009:2 37-43

Kazuhiro Nakamura1 and Hiroyuki Hasegawa2

1Department of Pathology, Juntendo University School of Medicine, Tokyo 113-8421, Japan. 2Department of Biosciences, Teikyo University of Science and Technology, Uenohara, Yamanashi 409-0193, Japan.

Abstract

Serotonin (5-hydroxytryptamine [5-HT]) has been implicated in a variety of physiological and pathological functions. Multiple steps of enzyme reactions enable biosynthesis of 5-HT. The first and rate-limiting step of the reaction is the synthesis of 5-hydroxy-L-tryptophan (5-HTP) from L-tryptophan. This step is dictated by an enzyme, tryptophan hydroxylase (TPH). TPH requires 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as a co-substrate of TPH. 5-HTP has been simply regarded as a precursor of 5-HT and it is believed that the biological significance of 5-HTP is essentially ascribed to the production of 5-HT. However, recent works shed light on the specific functions of 5-HTP in the periphery. In this review article, we focus on the specific roles of exogenous 5-HTP as well as the endogenous 5-HTP in the gut epithelial cells. Since systemic treatment with 5-HTP is applied to patients with lower 5-HT levels, the studies on the specific role of 5-HTP might create an opportunity to explore the effects of exogenously-applied 5-HTP in the gut in man.

Categories: Pharmacology


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