Journal of Experimental Neuroscience

When two tones are presented in a short interval of time, the presentation of the preceding tone (masker) suppresses the response evoked by the subsequent tone (signal). To address the processing in forward suppression, we applied 2- and 4-kHz maskers, followed by a 1-kHz signal at ­varying ­signal delays (0 to 320 ms) and measured the signal-evoked N1m. A two-way analysis of variance revealed a statistically significant effect for signal delay in both masker presentation conditions. The N1m peak amplitude at the signal delay of 320 ms was significantly larger than those of 10, 20, 40, and 80 ms (p , 0.05). No significant enhancement for the very short signal delay was observed. The results suggest that the enhancement of N1m peak amplitude for short signal delay conditions is maximized when the frequency of the masker is identical to that of the signal.