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Characterization of a Test for Invasive Breast Cancer Using X-ray Diffraction of Hair - Results of a Clinical Trial

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Publication Date: 10 Nov 2009

Journal: Breast Cancer: Basic and Clinical Research

Citation: Breast Cancer: Basic and Clinical Research 2009:3 83-90

BCbcr journal

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Abstract

Objective: To assess the performance of a test for breast cancer utilizing synchrotron x-ray diffraction analysis of scalp hair from women undergoing diagnostic radiology assessment.

Design and Setting: A double-blinded clinical trial of women who attended diagnostic radiology clinics in Australia.

Patients: 1796 women referred for diagnostic radiology, with no previous history of cancer.

Main Outcome Measures: Sensitivity, specificity and accuracy of the hair test analysis compared to the gold standard of imaging followed by biopsy where indicated.

Results: The hair-based assay had an overall accuracy of >77% and a negative predictive value of 99%. For all women, the sensitivity of both mammography and x-ray diffraction alone was 64%, but when used together the sensitivity rose to 86%. The sensitivity of the hair test for women under the age of 70 was 74%.

Conclusion: In this large population trial the association between the presence of breast cancer and an altered hair fibre X-ray diffraction pattern previously reported has been confirmed. It appears that mammography and X-ray diffraction of hair detect different populations of breast cancers, and are synergistic when used together.


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