TY - JOUR TI - Urinary Neutrophil Gelatinase-Associated Lipocalin to Monitor Lupus Nephritis Disease Activity AU - Susianti,Hani AU - Wijaya, Jullyanny W. AU - Rastini, Ati AU - Handono, Kusworini AU - Gunawan,Atma AU - Kalim,Handono PY - 2015/09/06 AB - Background: This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-β1 (uTGF-β1) with lupus nephritis (LN) disease activity. Methods: Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-β1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. Results: The uNGAL levels were significantly different between active and inactive LN (P < 0.05). uTGF- β1 levels were not different between active and inactive LN (P > 0.05). There was a significant correlation between uNGAL levels and renal domain SLEDAI score (r = 0.417, P < 0.05). There was no correlation between uTGF- β1 levels and renal domain SLEDAI score (r = 0.031, P > 0.05). Conclusion: uNGAL is better than uTGF- β1 for differentiation of active and inactive LN. uNGAL can be considered as a biomarker to monitor LN disease activity. KW - KW - DB - Libertas Academica DP - Libertas Academica LA - English SP - 81 EP - 87 JO - Biomarker Insights VL - 10 IS - Supplementary Material 27625 SN - UR - www.la-press.com/urinary-neutrophil-gelatinase-associated-lipocalin-to-monitor-lupus-ne-article-a5054 L1 - www.la-press.com/redirect_file.php?fileId=6764&filename=Supplementary Material 27625&fileType=docx DO - 10.4137/BMI.S27625 ER -