TY - JOUR TI - Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD AU - Furukawa,Hiroshi AU - Oka, Shomi AU - Shimada, Kota AU - Masuo, Kiyoe AU - Nakajima, Fumiaki AU - Funano, Shunichi AU - Tanaka, Yuki AU - Komiya, Akiko AU - Fukui, Naoshi AU - Sawasaki, Tatsuya AU - Tadokoro, Kenji AU - Nose, Masato AU - Tsuchiya,Naoyuki AU - Tohma,Shigeto PY - 2015/08/16 AB - Interstitial lung disease (ILD) is frequently associated with collagen disease. It is then designated as collagen vascular disease-associated ILD (CVD-ILD), and influences patients' prognosis. The prognosis of acute-onset diffuse ILD (AoDILD) occurring in patients with collagen disease is quite poor. Here, we report our investigation of auto-antibody (Ab) profiles to determine whether they may be useful in diagnosing CVD-ILD or AoDILD in collagen disease. Auto-Ab profiles were analyzed using the Lambda Array Beads Multi-Analyte System, granulocyte immunofluorescence test, ProtoArray Human Protein Microarray, AlphaScreen assay, and glutathione S-transferase capture enzyme-linked immunosorbent assay in 34 patients with rheumatoid arthritis (RA) with or without CVD-ILD and in 15 patients with collagen disease with AoDILD. The average anti-major histocompatibility complex class I-related chain A (MICA) Ab levels were higher in RA patients with CVD-ILD than in those without (P = 0.0013). The ratio of the average anti-MICA Ab level to the average anti-human leukocyte antigen class I Ab level (ie, MICA/Class I) was significantly higher in RA patients with CVD-ILD compared with those without (P = 4.47 × 10⁻⁵). To the best of our knowledge, this is the first report of auto-Ab profiles in CVD-ILD. The MICA/Class I ratio could be a better marker for diagnosing CVD-ILD than KL-6 (Krebs von den lungen-6). KW - KW - DB - Libertas Academica DP - Libertas Academica LA - English SP - 63 EP - 73 JO - Biomarker Insights VL - 10 IS - Supplementary Material 28209 SN - UR - www.la-press.com/autoantibody-profiles-in-collagen-disease-patients-with-interstitial-l-article-a5007 L1 - www.la-press.com/redirect_file.php?fileId=6705&filename=Supplementary Material 28209&fileType=zip DO - 10.4137/BMI.S28209 ER -