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JOURNAL

Cancer Informatics

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An Architecture for Computer-Aided Detection and Radiologic Measurement of Lung Nodules in Clinical Trials

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Publication Date: 12 May 2007

Journal: Cancer Informatics

Citation: Cancer Informatics 2007:4 25-31

Matthew S. Brown, Richard Pais, Peiyuan Qing, Sumit Shah, Michael F. McNitt-Gray, Jonathan G. Goldin, Iva Petkovska, Lien Tran and Denise R. Aberle

Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, U.S.A.

Abstract: Computer tomography (CT) imaging plays an important role in cancer detection and quantitative assessment in clinical trials. High-resolution imaging studies on large cohorts of patients generate vast data sets, which are infeasible to analyze through manual interpretation. In this article we describe a comprehensive architecture for computer-aided detection (CAD) and surveillance on lung nodules in CT images. Central to this architecture are the analytic components: an automated nodule detection system, nodule tracking capabilities and volume measurement, which are integrated within a data management system that includes mechanisms for receiving and archiving images, a database for storing quantitative nodule measurements and visualization, and reporting tools. We describe two studies to evaluate CAD technology within this architecture, and the potential application in large clinical trials. The fi rst study involves performance assessment of an automated nodule detection system and its ability to increase radiologist sensitivity when used to provide a second opinion. The second study investigates nodule volume measurements on CT made using a semi-automated technique and shows that volumetric analysis yields significantly different tumor response classifications than a 2D diameter approach. These studies demonstrate the potential of automated CAD tools to assist in quantitative image analysis for clinical trials.

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