Biomarker Insights

From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease (Published on 27 Apr 2015)

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MicroRNA-Seq Data Analysis Pipeline to Identify Blood Biomarkers for Alzheimer's Disease from Public Data (Published on 15 Apr 2015)

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Gene Delivery Strategies to Promote Spinal Cord Repair (Published on 09 Apr 2015)

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The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease (Published on 08 Apr 2015)

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Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis Among NHANES 2005–2008 Subjects (Published on 28 Jan 2015)

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Prednisolone-Induced Predisposition to Femoral Head Separation and the Accompanying Plasma Protein Changes in Chickens (Published on 14 Jan 2015)

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Risk Factors Associated with Serum Levels of the Inflammatory Biomarker Soluble Urokinase Plasminogen Activator Receptor in a General Population (Published on 16 Dec 2014)

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Decreased Mitogen Inducible Gene 6 (MIG-6) Associated with Symptom Severity in Children with Autism (Published on 06 Oct 2014)

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Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas (Published on 03 Sep 2014)

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Identification of Gene Signatures Used to Recognize Biological Characteristics of Gastric Cancer Upon Gene Expression Data (Published on 14 Aug 2014)

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Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin (Published on 27 Jul 2014)

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DNA Methylation at the Novel CpG Sites in the Promoter of MED15/PCQAP Gene as a Biomarker for Head and Neck Cancers (Published on 03 Jul 2014)

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 Video Abstract Available

Integrative Genomic Analysis for the Discovery of Biomarkers in Prostate Cancer (Published on 29 Jun 2014)

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Folate Receptor Alpha, Mesothelin and Megakaryocyte Potentiating Factor as Potential Serum Markers of Chronic Kidney Disease (Published on 25 May 2014)

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HLA-DRB1*08:02 Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients (Published on 19 May 2014)

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Prognostic Value of DNA and mRNA E6/E7 of Human Papillomavirus in the Evolution of Cervical Intraepithelial Neoplasia Grade 2 (Published on 13 Apr 2014)

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The Range of Uncertainty: a Tool for Efficiently Addressing Result Variability Around Clinical Decision Points for Hepatitis C Response-Guided Therapy (Published on 09 Apr 2014)

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Comment on "Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia" (Published on 23 Mar 2014)

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Utility of C-terminal Telopeptide in Evaluating Levothyroxine Replacement Therapy-Induced Bone Loss (Published on 03 Mar 2014)

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Quantification of Plasma miRNAs by Digital PCR for Cancer Diagnosis (Published on 14 Nov 2013)

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Perspectives on the Value of Biomarkers in Acute Cardiac Care and Implications for Strategic Management (Published on 03 Sep 2013)

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Decreased Hepatocyte Growth Factor (HGF) and Gamma Aminobutyric Acid (GABA) in Individuals with Obsessive-Compulsive Disorder (OCD) (Published on 18 Aug 2013)

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Markers that can Reflect Asthmatic Activity before and after Reduction of Inhaled Corticosteroids: A Pilot Study (Published on 04 Aug 2013)

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Identification of Potential Prognostic Markers for Knee Osteoarthritis by Serum Proteomic Analysis (Published on 29 Jul 2013)

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CIINE Reflects Collagenase-Specific CII Breakdown in Cartilage Explant and Whole Body of Canine (Published on 16 Jun 2013)

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Correlation Between Hepatocyte Growth Factor (HGF) and Gamma-Aminobutyric Acid (GABA) Plasma Levels in Autistic Children (Published on 12 Jun 2013)

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Biomarkers of Dose and Effect of Inhaled Ozone in Resting versus Exercising Human Subjects: Comparison with Resting Rats (Published on 19 May 2013)

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Oxidative Stress and DNA Damage Induced by Chromium in Liver and Kidney of Goldfish, Carassius auratus (Published on 25 Apr 2013)

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Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism (Published on 04 Apr 2013)

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Quantitative Appraisal of Ventricular Cerebrospinal Fluid Biomarkers in Neuropathologically Diagnosed Parkinson's Disease Cases Lacking Alzheimer's Disease Pathology (Published on 12 Mar 2013)

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A Further Study of the Role of Copper in Regard to the Antimutagenic Action of Sodium Copper Chlorophyllin (SCC) in Somatic Cells of Drosophila melanogaster (Published on 12 Mar 2013)

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Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) have Different Patterns in Heart Failure Exacerbation (Published on 11 Mar 2013)

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Personalized Medicine in Screening for Malignant Disease: A Review of Methods and Applications (Published on 18 Feb 2013)

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Lipid Profile of Patients with Acute Myocardial Infarction and its Correlation with Systemic Inflammation (Published on 24 Jan 2013)

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Circulating Levels of a Collagen Type V Propeptide Fragment in a Carbon Tetrachloride Reversible Model of Liver Fibrosis (Published on 17 Dec 2012)

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Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families (Published on 12 Dec 2012)

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Associations of Circulating Inflammatory Biomarkers with Risk Factors for Colorectal Cancer in Colorectal Adenoma Patients (Published on 05 Nov 2012)

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Knowledge Building Insights on Biomarkers of Arsenic Toxicity to Keratinocytes and Melanocytes (Published on 15 Oct 2012)

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Serological Investigation of the Collagen Degradation Profile of Patients with Chronic Obstructive Pulmonary Disease or Idiopathic Pulmonary Fibrosis (Published on 13 Sep 2012)

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Molecular Serum Markers of Liver Fibrosis (Published on 23 Jul 2012)

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Biomarkers of Disease and Treatment in Murine and Cynomolgus Models of Chronic Asthma (Published on 10 Jul 2012)

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Circulating Immune Complex Levels are Associated with Disease Severity and Seasonality in Children with Malaria from Mali (Published on 03 Jul 2012)

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Characterization of Antibodies that Detect Human GFAP after Traumatic Brain Injury (Published on 25 Jun 2012)

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Prognosis of Treatment Response (Pathological Complete Response) in Breast Cancer (Published on 08 May 2012)

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Novel Cardiac-Specific Biomarkers and the Cardiovascular Continuum (Published on 02 May 2012)

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The Prognostic Value of suPAR Compared to Other Inflammatory Markers in Patients with Severe Sepsis (Published on 10 Apr 2012)

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Increased Levels of Circulating and Tissue mRNAs of Oct-4, Sox-2, Bmi-1 and Nanog is ESCC Patients: Potential Tool for Minimally Invasive Cancer Diagnosis (Published on 26 Mar 2012)

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Evaluation of Ischemia-Modified Albumin and C-Reactive Protein in Type 2 Diabetics With and Without Ketosis (Published on 14 Mar 2012)

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Detection of 1p19q Deletion by Real-Time Comparative Quantitative PCR (Published on 01 Feb 2012)

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Overcoming the Effects of Matrix Interference in the Measurement of Urine Protein Analytes (Published on 01 Feb 2012)

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Association between Perchlorate and Indirect Indicators of Thyroid Dysfunction in Nhanes 2001–2002, a Cross-Sectional, Hypothesis-Generating Study (Published on 01 Dec 2011)

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Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism (Published on 08 Nov 2011)

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Detection of suPAR in the Saliva of Healthy Young Adults: Comparison with Plasma Levels (Published on 25 Oct 2011)

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The Primary Cilium as a Biomarker in the Hypoxic Adaptation of Bone Marrow-Derived Mesenchymal Stromal Cells: A Role for the Secreted Frizzled-Related Proteins (Published on 29 Sep 2011)

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Levels of Circulating MMCN-151, a Degradation Product of Mimecan, Reflect Pathological Extracellular Matrix Remodeling in Apolipoprotein E Knockout Mice (Published on 22 Sep 2011)

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Erratum for “Aberrantly Expressed Genes in HaCaT Keratinocytes Chronically Exposed to Arsenic Trioxide” (Published on 08 Sep 2011)

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Plasma Soluble Urokinase Plasminogen Activator Receptor in Children with Urinary Tract Infection (Published on 16 Aug 2011)

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Building Multi-Marker Algorithms for Disease Prediction—The Role of Correlations Among Markers (Published on 14 Aug 2011)

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Comparison of Liquid Chromatography–Tandem Mass Spectrometry and Sandwich ELISA for Determination of Keratan Sulfate in Plasma and Urine (Published on 27 Jun 2011)

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Changes in Plasma Fibronectin Isoform Levels Predict Distinct Clinical Outcomes in Critically Ill Patients (Published on 29 May 2011)

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Measurement of CO3-610, a Potential Liver Biomarker Derived from Matrix Metalloproteinase-9 Degradation of Collagen Type III, in a Rat Model of Reversible Carbon-Tetrachloride-Induced Fibrosis (Published on 24 Mar 2011)

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1H HRMAS NMR Derived Bio-markers Related to Tumor Grade, Tumor Cell Fraction, and Cell Proliferation in Prostate Tissue Samples (Published on 14 Mar 2011)

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Uncarinic Acid C Isolated from Uncaria rhynchophylla Induces Differentiation of Th1-Promoting Dendritic Cells Through TLR4 Signaling (Published on 28 Feb 2011)

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FXYD3: A Promising Biomarker for Urothelial Carcinoma (Published on 15 Feb 2011)

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Aberrantly Expressed Genes in HaCaT Keratinocytes Chronically Exposed to Arsenic Trioxide (Published on 08 Feb 2011)

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Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels During Normal Pregnancy (Published on 12 Jan 2011)

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Establishment of Prognostic Models for Astrocytic and Oligodendroglial Brain Tumors with Standardized Quantification of Marker Gene Expression and Clinical Variables (Published on 22 Dec 2010)

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Identification of Unique Blood and Urine Biomarkers in Influenza Virus and Staphylococcus aureus Co-infection: A Preliminary Study (Published on 05 Dec 2010)

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Stabilizing the Code—Methods to Preserve RNA Prove Their Worth (Published on 01 Dec 2010)

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Validated Sandwich ELISA for the Quantification of von Willebrand Factor in Rabbit Plasma (Published on 28 Nov 2010)

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Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer (Published on 28 Nov 2010)

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Breast Cancer Biomarker Discovery in the Functional Genomic Age: A Systematic Review of 42 Gene Expression Signatures (Published on 27 Oct 2010)

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Assessment of mRNA and microRNA Stabilization in Peripheral Human Blood for Multicenter Studies and Biobanks (Published on 22 Sep 2010)

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Diagnostic Markers for Tuberculosis Ascites: A Preliminary Study (Published on 25 Aug 2010)

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Standardization of Gene Expression Quantification by Absolute Real-Time qRT-PCR System Using a Single Standard for Marker and Reference Genes (Published on 16 Aug 2010)

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LSOSS: Detection of Cancer Outlier Differential Gene Expression (Published on 05 Aug 2010)

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Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Depression Correlates with Severity of Disease (Published on 03 Aug 2010)

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Detection of Homocysteine and C-Reactive Protein in the Saliva of Healthy Adults: Comparison with Blood Levels (Published on 02 Jul 2010)

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Feasibility of High-Throughput Genome-Wide Genotyping using DNA from Stored Buccal Cell Samples (Published on 20 May 2010)

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Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia (Published on 12 May 2010)

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Elevated Serum Sorbitol and not Fructose in Type 2 Diabetic Patients (Published on 04 May 2010)

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The Common FTO Genetic Polymorphism rs9939609 is Associated with Increased BMI in Type 1 Diabetes  but not with Diabetic Nephropathy (Published on 27 Apr 2010)

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Association of CYP1B1 Polymorphisms with Breast Cancer: A Case-Control Study in the Han Population in Ningxia Hui Autonomous Region, P. R. China (Published on 12 Feb 2010)

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Immunohistochemistry as an Important Tool in Biomarkers Detection and Clinical Practice (Published on 09 Feb 2010)

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Assessment of Confounding Factors Affecting the Tumor Markers SMRP, CA125, and CYFRA21-1 in Serum (Published on 28 Jan 2010)

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Enhanced Expression of Radiation-Induced Leukocyte CDKN1A mRNA in Multiple Primary Breast Cancer Patients: Potential New Marker of Cancer Susceptibility (Published on 22 Dec 2009)

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Protein Modifications as Potential Biomarkers in Breast Cancer (Published on 30 Nov 2009)

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Decreased Serum Hepatocyte Growth Factor (HGF) in Autistic Children with Severe Gastrointestinal Disease (Published on 27 Nov 2009)

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Biomarker Validation for Aging: Lessons from mtDNA Heteroplasmy Analyses in Early Cancer Detection (Published on 27 Nov 2009)

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An Optimal Protocol to Analyze the Rat Spinal Cord Proteome (Published on 28 Oct 2009)

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Biomarkers of Adiponectin: Plasma Protein Variation and Genomic DNA Polymorphisms (Published on 13 Oct 2009)

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Changes in Plasma IL-6, Plasma VEGF and Serum YKL-40 During Treatment with Etanercept and Methotrexate or Etanercept Alone in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy (Published on 29 Sep 2009)

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Novel Biomarkers for the Diagnosis of Urinary Tract Infection - A Systematic Review (Published on 05 Aug 2009)

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Joint Variable Selection and Classification with Immunohistochemical Data (Published on 22 Jul 2009)

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Angiotensin II Type 1 Receptor Blockers Reduce Urinary Angiotensinogen Excretion and the Levels of Urinary Markers of Oxidative Stress and Inflammation in Patients with Type 2 Diabetic Nephropathy (Published on 23 Jun 2009)

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Pathway Analysis of Differentially Expressed Genes in Patients with Acute Aortic Dissection (Published on 06 May 2009)

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Investigating Multi-cancer Biomarkers and Their Cross-predictability in the Expression Profiles of Multiple Cancer Types (Published on 01 May 2009)

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Plasma Carotenoids and Biomarkers of Oxidative Stress in Patients with prior Head and Neck Cancer (Published on 23 Mar 2009)

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Low Serum Alpha-1 Antitrypsin (AAT) in Family Members of Individuals with Autism Correlates with PiMZ Genotype (Published on 18 Mar 2009)

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Cartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis (Published on 17 Feb 2009)

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Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk (Published on 09 Feb 2009)

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Breath Hydrogen Gas Concentration Linked to Intestinal Gas Distribution and Malabsorption in Patients with Small-bowel Pseudo-obstruction (Published on 15 Jan 2009)

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Gene Expression in Hair Follicle Dermal Papilla Cells after Treatment with Stanozolol (Published on 23 Dec 2008)

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Biomarkers in Acute Coronary Syndrome (Published on 05 Nov 2008)

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Radionuclide-Based Cancer Imaging Targeting the Carcinoembryonic Antigen (Published on 23 Sep 2008)

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Clinical Performance of a Salivary Amylase Activity Monitor During Hemodialysis Treatment (Published on 15 Sep 2008)

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Hematopoietic Lineage Transcriptome Stability and Representation in PAXgeneTM Collected Peripheral Blood Utilising SPIA Single-Stranded cDNA Probes for Microarray (Published on 25 Aug 2008)

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Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells (Published on 08 Jul 2008)

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Pulmonary Biomarkers of Bronchopulmonary Dysplasia (Published on 02 Jul 2008)

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Detection of Colorectal Cancer by Serum and Tissue Protein Profiling: A Prospective Study in a Population at Risk (Published on 02 Jul 2008)

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Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity (Published on 10 Jun 2008)

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Proteomics Discovery of Disease Biomarkers (Published on 06 Jun 2008)

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Activation of Tissue Remodeling Precedes Obliterative Bronchiolitis in Lung Transplant Recipients (Published on 06 Jun 2008)

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Alzheimer’s Disease, Diagnosis and the Need for Biomarkers (Published on 27 May 2008)

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Serum Concentrations of F2-Isoprostanes and 4-Hydroxynonenal in Hemodialysis Patients in Relation to Inflammation and Renal Anemia (Published on 27 May 2008)

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Biomarkers and Bioassays for Cardiovascular Diseases: Present and Future (Published on 19 May 2008)

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MUC1 as a Putative Prognostic Marker for Prostate Cancer (Published on 14 May 2008)

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Changes in Hyaluronan Metabolism and RHAMM Receptor Expression Accompany Formation of Complicated Carotid Lesions and May be Pro-Angiogenic Mediators of Intimal Neovessel Growth (Published on 12 May 2008)

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What is New on Thyroid Cancer Biomarkers (Published on 29 Apr 2008)

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DICER1 and PRKRA in Colon Adenocarcinoma (Published on 28 Apr 2008)

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A Rapid and Simple Bioassay Method for Herbicide Detection (Published on 28 Apr 2008)

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Dendritic Cells Promoted by Ginseng Saponins Drive a Potent Th1 Polarization (Published on 18 Apr 2008)

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Comparison of the Calibration Standards of Three Commercially Available Multiplex Kits for Human Cytokine Measurement to WHO Standards Reveals Striking Differences (Published on 18 Apr 2008)

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Excision Repair Cross-Complementation Group 1 Enzyme as a Molecular Determinant of Responsiveness to Platinum-Based Chemotherapy for non Small-Cell Lung Cancer (Published on 17 Apr 2008)

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Biomarkers of Ovarian Reserve (Published on 16 Apr 2008)

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Novel Biomarkers Associated with Deep Venous Thrombosis: A Comprehensive Review (Published on 10 Apr 2008)

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The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis (Published on 28 Mar 2008)

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Time Dependent Gene Expression Changes in the Liver of Mice Treated with Benzene (Published on 28 Mar 2008)

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Chemical Biomarkers of Human Breast Milk Pollution (Published on 28 Mar 2008)

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Usefulness of B Natriuretic Peptides and Procalcitonin in Emergency Medicine (Published on 27 Mar 2008)

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FTIR Microspectroscopy Coupled with Two-Class Discrimination Segregates Markers Responsible for Inter- and Intra-Category Variance in Exfoliative Cervical Cytology (Published on 25 Mar 2008)

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Serum and Ascitic Fluid Superoxide Dismutase and Malondialdehyde Levels in Patients with Cirrhosis (Published on 12 Mar 2008)

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Circulating Markers Reflect Both Anti- and Pro-Atherogenic Drug Effects in ApoE-Deficient Mice (Published on 12 Mar 2008)

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Proteomic Biomarkers of Atherosclerosis (Published on 12 Mar 2008)

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An Evaluation of the Clinical Evidence on the Role of Inflammation and Oxidative Stress in Smoking-Mediated Cardiovascular Disease (Published on 01 Mar 2008)

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Repeatedly Heading a Soccer Ball Does Not Increase Serum Levels of S-100B, a Biochemical Marker of Brain Tissue Damage: an Experimental Study (Published on 29 Feb 2008)

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Biomarkers in Acute Kidney Injury (Published on 26 Feb 2008)

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Cellular Adhesion Molecules in Healthy Subjects: Short Term Variations and Relations to Flow Mediated Dilation (Published on 14 Feb 2008)

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Expression of Osteoarthritis Marker YKL-39 is Stimulated by Transforming Growth Factor Beta (TGF-beta) and IL-4 in Differentiating Macrophages (Published on 14 Feb 2008)

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Genomic and Proteomic Biomarker Discovery in Neurological Disease (Published on 09 Feb 2008)

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Candidate List of yoUr Biomarker (CLUB): A Web-based Platform to Aid Cancer Biomarker Research (Published on 09 Feb 2008)

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Sample Stability and Protein Composition of Saliva: Implications for Its Use as a Diagnostic Fluid (Published on 01 Feb 2008)

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Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer (Published on 01 Feb 2008)

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Marker of Bone Resorption in Acute Response to Exogenous or Endogenous Parathyroid Hormone (Published on 25 Jan 2008)

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DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer (Published on 25 Jan 2008)

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Antibody Arrays Identify Potential Diagnostic Markers of Hepatocellular Carcinoma (Published on 21 Jan 2008)

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Increased Intrathecal Chemokine Receptor CCR2 Expression in Multiple Sclerosis (Published on 18 Dec 2007)

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Using LongSAGE to Detect Biomarkers of Cervical Cancer Potentially Amenable to Optical Contrast Agent Labelling (Published on 11 Dec 2007)

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Clastogenic Factors as Potential Biomarkers of Increased Superoxide Production (Published on 11 Dec 2007)

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An EGFR and AKT Signaling Pathway was Identified with Mediation Model in Osteosarcomas Clinical Study (Published on 11 Dec 2007)

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